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. 1982 Jan 1;155(1):52–60. doi: 10.1084/jem.155.1.52

Tthyd, a new thymocyte alloantigen linked to Igh-1. Implications for a switch mechanism for T cell antigen receptors

PMCID: PMC2186581  PMID: 6976417

Abstract

Tthyd is an alloantigen coded for by a gene(s) near the immunoglobulin locus on chromosome 12 in the mouse. This T cell-specific antigen may be the third member of a family of antigen receptors on T cells encoded by a cluster of genes in the IgT-C region. This antigen is preferentially expressed on thymocytes in contrast to Tindd or Tsud that are expressed on peripheral T cells. The hypothesis that T cell receptors undergo a switch in surface isotype upon maturation is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bernard O., Hozumi N., Tonegawa S. Sequences of mouse immunoglobulin light chain genes before and after somatic changes. Cell. 1978 Dec;15(4):1133–1144. doi: 10.1016/0092-8674(78)90041-7. [DOI] [PubMed] [Google Scholar]
  2. Besedovsky H. O., del Rey A., Sorkin E. Role of prethymic cells in acquisition of self-tolerance. J Exp Med. 1979 Dec 1;150(6):1351–1358. doi: 10.1084/jem.150.6.1351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bevan M. J. In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature. 1977 Sep 29;269(5627):417–418. doi: 10.1038/269417a0. [DOI] [PubMed] [Google Scholar]
  4. Eardley D. D., Shen F. W., Cone R. E., Gershon R. K. Antigen-binding T cells: dose response and kinetic studies on the development of different subsets. J Immunol. 1979 Jan;122(1):140–145. [PubMed] [Google Scholar]
  5. Eichmann K., Rajewsky K. Induction of T and B cell immunity by anti-idiotypic antibody. Eur J Immunol. 1975 Oct;5(10):661–666. doi: 10.1002/eji.1830051002. [DOI] [PubMed] [Google Scholar]
  6. Greene M. I., Sy M. S., Nisonoff A., Benacerraf B. The genetic and cellular basis of antigen and receptor stimulated regulation. Mol Immunol. 1980 Jul;17(7):857–866. doi: 10.1016/0161-5890(80)90034-6. [DOI] [PubMed] [Google Scholar]
  7. Honjo T., Kataoka T. Organization of immunoglobulin heavy chain genes and allelic deletion model. Proc Natl Acad Sci U S A. 1978 May;75(5):2140–2144. doi: 10.1073/pnas.75.5.2140. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jerne N. K. Towards a network theory of the immune system. Ann Immunol (Paris) 1974 Jan;125C(1-2):373–389. [PubMed] [Google Scholar]
  9. Krawinkel U., Cramer M., Imanishi-Kari T., Jack R. S., Rajewsky K., Mäkelä O. Isolated hapten-binding receptors of sensitized lymphocytes. I. Receptors from nylon wool-enriched mouse T lymphocytes lack serological markers of immunoglobulin constant domains but express heavy chain variable portions. Eur J Immunol. 1977 Aug;7(8):566–573. doi: 10.1002/eji.1830070814. [DOI] [PubMed] [Google Scholar]
  10. Kronenberg M., Davis M. M., Early P. W., Hood L. E., Watson J. D. Helper and killer T cells do not express B cell immunoglobulin joining and constant region gene segments. J Exp Med. 1980 Dec 1;152(6):1745–1761. doi: 10.1084/jem.152.6.1745. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kurosawa Y., von Boehmer H., Haas W., Sakano H., Trauneker A., Tonegawa S. Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes. Nature. 1981 Apr 16;290(5807):565–570. doi: 10.1038/290565a0. [DOI] [PubMed] [Google Scholar]
  12. Köhler G., Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975 Aug 7;256(5517):495–497. doi: 10.1038/256495a0. [DOI] [PubMed] [Google Scholar]
  13. LITTLEFIELD J. W. SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS. Science. 1964 Aug 14;145(3633):709–710. doi: 10.1126/science.145.3633.709. [DOI] [PubMed] [Google Scholar]
  14. Nisonoff A., Ju S. T., Owen F. L. Studies of structure and immunosuppression of cross-reactive idiotype in strain A mice. Immunol Rev. 1977;34:89–118. doi: 10.1111/j.1600-065x.1977.tb00369.x. [DOI] [PubMed] [Google Scholar]
  15. Owen F. L. A mature T lymphocyte marker closely linked to Igh-1 that is expressed on the precursor for the suppressor T cell regulating a primary response to SRBC. J Immunol. 1980 Mar;124(3):1411–1417. [PubMed] [Google Scholar]
  16. Owen F. L., Finnegan A., Gates E. R., Gottlieb P. D. A mature T lymphocyte subpopulation marker closely linked to the Ig-1 allotype Ch locus. Eur J Immunol. 1979 Dec;9(12):948–955. doi: 10.1002/eji.1830091208. [DOI] [PubMed] [Google Scholar]
  17. Owen F. L., Ju S. T., Nisonoff A. Binding to idiotypic determinants of large proportions of thymus-derived lymphocytes in idiotypically suppressed mice. Proc Natl Acad Sci U S A. 1977 May;74(5):2084–2088. doi: 10.1073/pnas.74.5.2084. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Owen F. L. Polyclonal activation of Ts cells with antiserum directed against an IGH-1 linked candidate for a T-cell receptor constant region marker. J Supramol Struct. 1980;14(2):175–182. doi: 10.1002/jss.400140206. [DOI] [PubMed] [Google Scholar]
  19. Owen F. L., Riblet R., Taylor B. A. The T suppressor cell alloantigen Tsud maps near immunoglobulin allotype genes and may be an heavy chain constant-region marker on a T cell receptor. J Exp Med. 1981 Apr 1;153(4):801–810. doi: 10.1084/jem.153.4.801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Pacifico A., Capra J. D. T cell hybrids with arsonate specificity. I. Initial characterization of antigen-specific T cell products that bear a cross-reactive idiotype and determinants encoded by the murine major histocompatibility complex. J Exp Med. 1980 Nov 1;152(5):1289–1301. doi: 10.1084/jem.152.5.1289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Spurll G. M., Owen F. L. A family of T-cell alloantigens linked to Igh-1. Nature. 1981 Oct 29;293(5835):742–745. doi: 10.1038/293742a0. [DOI] [PubMed] [Google Scholar]
  22. Spurll G. M., Owen F. L. Development of a cell line secreting monoclonal antibody specific for concanavalin A and use of that antibody as an affinity immunosorbent for tissue culture media used to support long-term T cell growth. J Immunol Methods. 1980;39(4):335–341. doi: 10.1016/0022-1759(80)90233-1. [DOI] [PubMed] [Google Scholar]
  23. Wekerle H., Ketelsen U. P., Ernst M. Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization. J Exp Med. 1980 Apr 1;151(4):925–944. doi: 10.1084/jem.151.4.925. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Woodland R., Cantor H. Idiotype-specific T helper cells are required to induce idiotype-positive B memory cells to secrete antibody. Eur J Immunol. 1978 Aug;8(8):600–606. doi: 10.1002/eji.1830080812. [DOI] [PubMed] [Google Scholar]
  25. Zinkernagel R. M., Althage A., Callahan G. Thymic reconstitution of nude F1 mice with one or both parental thymus grafts. J Exp Med. 1979 Sep 19;150(3):693–697. doi: 10.1084/jem.150.3.693. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Zinkernagel R. M. H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras. J Exp Med. 1976 Oct 1;144(4):933–945. doi: 10.1084/jem.144.4.933. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Zinkernagel R. M. Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control. Immunol Rev. 1978;42:224–270. doi: 10.1111/j.1600-065x.1978.tb00264.x. [DOI] [PubMed] [Google Scholar]

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