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. 1969 Dec;64(4):1235–1241. doi: 10.1073/pnas.64.4.1235

PEPTIDE CHAIN TERMINATION, V. THE ROLE OF RELEASE FACTORS IN MRNA TERMINATOR CODON RECOGNITION

E M Scolnick 1, C T Caskey 1
PMCID: PMC223274  PMID: 4916922

Abstract

The protein release factors, R1 and R2, bind to ribosomes in response to specific terminator codons (R1 to UAA or UAG, R2 to UAA or UGA). In reactions containing ribosomes, the tritiated oligonucleotide UA[3H](A)2 is retained on nitrocellulose filters in response to either R1 or R2, and UA[3H]G in response to R1. These results indicate that an R·terminator codon·70S ribosome intermediate occurs during terminator codon recognition and suggest that protein release factors R1 and R2 recognize terminator codons.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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