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. 1973 Mar;113(3):1091–1095. doi: 10.1128/jb.113.3.1091-1095.1973

Close Linkage of the Genes serC (for Phosphohydroxy Pyruvate Transaminase) and serS (for Seryl-Transfer Ribonucleic Acid Synthetase) in Escherichia coli K-12

S J Clarke a,1, B Low b, W H Konigsberg c
PMCID: PMC251668  PMID: 4570768

Abstract

Escherichia coli strain K28, isolated after nitrosoguanidine mutagenesis, was found to be auxotrophic for serine. It was also temperature sensitive for growth as a result of producing an altered seryl-transfer ribonucleic acid (tRNA) synthetase (EC 6.1.1.11, l-serine: tRNA ligase [AMP]). The auxotrophy was caused by a mutation in the structural gene for phosphohydroxy-pyruvate transaminase (serC), which was distinct from, but closely linked to, the structural gene for seryl-tRNA synthetase (serS). We conclude that the relevant genes are in the order gal-serS-serC-aroA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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