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. 1984 May;50(2):445–450. doi: 10.1128/jvi.50.2.445-450.1984

Antiviral and protein-inducing activities of recombinant human leukocyte interferons and their hybrids.

G C Sen, R Herz, V Davatelis, S Pestka
PMCID: PMC255644  PMID: 6200607

Abstract

The antiviral activities of recombinant human leukocyte interferons IFN-alpha A and IFN-alpha D as well as five hybrids of these interferons against retroviruses, vesicular stomatitis virus, and encephalomyocarditis virus were studied in feline, human, and murine cells. Although these interferon species had widely different potencies, their activities against these viruses were, in general, proportional. The IFN-alpha A/D (Bgl) hybrid was the most potent species, and the IFN-alpha D/A (Bgl) hybrid was the least potent. However, the latter species did not interfere with the action of the former species. Like natural human leukocyte interferon, each of the seven species of recombinant interferons induced the synthesis of at least five proteins in human fibroblasts, whereas induction of only one such protein was readily detected in a feline fibroblast line in which these interferon species inhibited the replication of all three viruses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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