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. 1970 Feb;65(2):430–437. doi: 10.1073/pnas.65.2.430

Peptide Chain Termination, VI. Purification and Site of Action of S

J Goldstein 1, G Milman 1,*, E Scolnick 1, T Caskey 1
PMCID: PMC282921  PMID: 4905675

Abstract

Peptide chain termination is a result of at least two events: terminator codon recognition and hydrolysis of peptidyl tRNA. A protein factor S, isolated from the supernatant of Escherichia coli B, stimulates fMet release. Factor S lowers the Km for terminator trinucleotides without altering the Vmax of release and therefore acts at terminator codon recognition. The S protein differs from initiation factors, elongation factor G, several forms of elongation factor T and release factors. The importance of the 2% Tu content in purified S is unresolved.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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