Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1968 Nov;61(3):1042–1049. doi: 10.1073/pnas.61.3.1042

Ribosome-catalyzed peptidyl transfer: substrate specificity at the P-site.

R E Monro, J Cerná, K A Marcker
PMCID: PMC305433  PMID: 4879821

Full text

PDF
1042

Images in this article

1044Image
on p.1044

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J. S., Bretscher M. S., Clark B. F., Marcker K. A. A GTP requirement for binding initiator tRNA to ribosomes. Nature. 1967 Jul 29;215(5100):490–492. doi: 10.1038/215490a0. [DOI] [PubMed] [Google Scholar]
  2. Anderson J. S., Dahlberg J. E., Bretscher M. S., Revel M., Clark B. F. GTP-stimulated binding of initiator-tRNA to ribosomes directed by f2 bacteriophage RNA. Nature. 1967 Dec 16;216(5120):1072–1076. doi: 10.1038/2161072a0. [DOI] [PubMed] [Google Scholar]
  3. BERG P., LAGERKVIST U., DIECKMANN M. The enzymic synthesis of amino acyl derivatives of ribonucleic acid. VI. Nucleotide sequences adjacent to the ... pCpCpA end groups of isoleucine- and leucine-specific chains. J Mol Biol. 1962 Aug;5:159–171. doi: 10.1016/s0022-2836(62)80081-3. [DOI] [PubMed] [Google Scholar]
  4. Bretscher M. S. Fractionation of oligolysyl-adenosine complexes derived from polylysine attached to sRNA. J Mol Biol. 1965 Jul;12(3):913–917. doi: 10.1016/s0022-2836(65)80337-0. [DOI] [PubMed] [Google Scholar]
  5. Bretscher M. S., Marcker K. A. Polypeptidyl-sigma-ribonucleic acid and amino-acyl-sigma-ribonucleic acid binding sites on ribosomes. Nature. 1966 Jul 23;211(5047):380–384. doi: 10.1038/211380a0. [DOI] [PubMed] [Google Scholar]
  6. Bretscher M. S. Polypeptide chain initiation and the characterization of ribosomal binding sites in E. coli. Cold Spring Harb Symp Quant Biol. 1966;31:289–295. doi: 10.1101/sqb.1966.031.01.038. [DOI] [PubMed] [Google Scholar]
  7. Clark B. F., Marcker K. A. The role of N-formyl-methionyl-sRNA in protein biosynthesis. J Mol Biol. 1966 Jun;17(2):394–406. doi: 10.1016/s0022-2836(66)80150-x. [DOI] [PubMed] [Google Scholar]
  8. Dube S. K., Marcker K. A., Clark B. F., Cory S. Nucleotide sequence of N-formyl-methionyl-transfer RNA. Nature. 1968 Apr 20;218(5138):232–233. doi: 10.1038/218232a0. [DOI] [PubMed] [Google Scholar]
  9. Economou A. E., Nakamoto T. Further studies on the initiation of protein synthesis with N-formylmethionine in E. coli extracts. Proc Natl Acad Sci U S A. 1967 Sep;58(3):1033–1039. doi: 10.1073/pnas.58.3.1033. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. GILBERT W. Polypeptide synthesis in Escherichia coli. II. The polypeptide chain and S-RNA. J Mol Biol. 1963 May;6:389–403. doi: 10.1016/s0022-2836(63)80051-0. [DOI] [PubMed] [Google Scholar]
  11. Ghosh H. P., Khorana H. G. Studies on polynucleotides, LXXXIV. On the role of ribosomal subunits in protein synthesis. Proc Natl Acad Sci U S A. 1967 Dec;58(6):2455–2461. doi: 10.1073/pnas.58.6.2455. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. HECHT L. I., ZAMECNIK P. C., STEPHENSON M. L., SCOTT J. F. Nucleoside tri-phosphates as precursors of ribonucleic acid end groups in a mammalian system. J Biol Chem. 1958 Oct;233(4):954–963. [PubMed] [Google Scholar]
  13. Haenni A. L., Chapeville F. The behaviour of acetylphenylalanyl soluble ribonucleic acid in polyphenylalanine synthesis. Biochim Biophys Acta. 1966 Jan 18;114(1):135–148. doi: 10.1016/0005-2787(66)90261-9. [DOI] [PubMed] [Google Scholar]
  14. Leder P., Bursztyn H. Initiation of protein synthesis II. A convenient assay for the ribosome-dependent synthesis of N-formyl-C14-methionylpuromycin. Biochem Biophys Res Commun. 1966 Oct 20;25(2):233–238. doi: 10.1016/0006-291x(66)90586-9. [DOI] [PubMed] [Google Scholar]
  15. Leder P., Nau M. M. Initiation of protein synthesis. 3. Factor-GTP-codon-dependent binding of F-met-tRNA to ribosomes. Proc Natl Acad Sci U S A. 1967 Aug;58(2):774–781. doi: 10.1073/pnas.58.2.774. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Lucas-Lenard J., Lipmann F. Initiation of polyphenylalanine synthesis by N-acetylphenylalanyl-SRNA. Proc Natl Acad Sci U S A. 1967 Apr;57(4):1050–1057. doi: 10.1073/pnas.57.4.1050. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Maden B. E., Traut R. R., Monro R. E. Ribosome-catalysed peptidyl transfer: the polyphenylalanine system. J Mol Biol. 1968 Jul 28;35(2):333–345. doi: 10.1016/s0022-2836(68)80028-2. [DOI] [PubMed] [Google Scholar]
  18. Marcker K. The formation of N-formyl-methionyl-sRNA. J Mol Biol. 1965 Nov;14(1):63–70. doi: 10.1016/s0022-2836(65)80230-3. [DOI] [PubMed] [Google Scholar]
  19. Monro R. E. Catalysis of peptide bond formation by 50 S ribosomal subunits from Escherichia coli. J Mol Biol. 1967 May 28;26(1):147–151. doi: 10.1016/0022-2836(67)90271-9. [DOI] [PubMed] [Google Scholar]
  20. Monro R. E., Marcker K. A. Ribosome-catalysed reaction of puromycin with a formylmethionine-containing oligonucleotide. J Mol Biol. 1967 Apr 28;25(2):347–350. doi: 10.1016/0022-2836(67)90146-5. [DOI] [PubMed] [Google Scholar]
  21. Monro R. E., Vazquez D. Ribosome-catalysed peptidyl transfer: effects of some inhibitors of protein synthesis. J Mol Biol. 1967 Aug 28;28(1):161–165. doi: 10.1016/s0022-2836(67)80085-8. [DOI] [PubMed] [Google Scholar]
  22. Mukundan M. A., Hershey J. W., Dewey K. F., Thach R. E. Binding of formylmethionyl-tRNA to 30S ribosomal sub-units. Nature. 1968 Mar 16;217(5133):1013–1016. doi: 10.1038/2171013a0. [DOI] [PubMed] [Google Scholar]
  23. NATHANS D., LIPMANN F. Amino acid transfer from aminoacyl-ribonucleic acids to protein on ribosomes of Escherichia coli. Proc Natl Acad Sci U S A. 1961 Apr 15;47:497–504. doi: 10.1073/pnas.47.4.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. NATHANS D., NEIDLE A. Structural requirements for puromycin inhibition of protein synthesis. Nature. 1963 Mar 16;197:1076–1077. doi: 10.1038/1971076a0. [DOI] [PubMed] [Google Scholar]
  25. Nomura M., Lowry C. V. PHAGE f2 RNA-DIRECTED BINDING OF FORMYLMETHIONYL-TRNA TO RIBOSOMES AND THE ROLE OF 30S RIBOSOMAL SUBUNITS IN INITIATION OF PROTEIN SYNTHESIS. Proc Natl Acad Sci U S A. 1967 Sep;58(3):946–953. doi: 10.1073/pnas.58.3.946. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Salas M., Miller M. J., Wahba A. J., Ochoa S. Translation of the genetic message. V. Effect of Mg++ and formylation of methionine in protein synthesis. Proc Natl Acad Sci U S A. 1967 Jun;57(6):1865–1869. doi: 10.1073/pnas.57.6.1865. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Sanger F., Brownlee G. G., Barrell B. G. A two-dimensional fractionation procedure for radioactive nucleotides. J Mol Biol. 1965 Sep;13(2):373–398. doi: 10.1016/s0022-2836(65)80104-8. [DOI] [PubMed] [Google Scholar]
  28. Waller J. P., Erdös T., Lemoine F., Guttmann S., Sandrin E. Inhibition of protein synthesis by aminoacyl 3'-(2')-adenosine. Biochim Biophys Acta. 1966 Jun 22;119(3):566–580. doi: 10.1016/0005-2787(66)90133-x. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES