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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1981 May;78(5):3123–3127. doi: 10.1073/pnas.78.5.3123

Leukocyte and fibroblast interferon genes are located on human chromosome 9.

D Owerbach, W J Rutter, T B Shows, P Gray, D V Goeddel, R M Lawn
PMCID: PMC319512  PMID: 6166943

Abstract

At least eight leukocyte interferon genes (IFL) and the single fibroblast interferon gene (IFF) have been located on chromosome 9 in humans. In somatic cell hybrids of human and mouse cells containing a normal complement of mouse parental cell chromosomes but reduced numbers of human chromosomes, the human leukocyte and fibroblast interferon DNA sequences were present only when human chromosome 9 was also present.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen G., Fantes K. H. A family of structural genes for human lymphoblastoid (leukocyte-type) interferon. Nature. 1980 Oct 2;287(5781):408–411. doi: 10.1038/287408a0. [DOI] [PubMed] [Google Scholar]
  2. Champion M. J., Brown J. A., Shows T. B. Assignment of cytoplasmic alpha-mannosidase (MANA) and confirmation of mitochondrial isocitrate dehydrogenase (IDHM) to the q11 leads to qter region of chromosome 15 in man. Cytogenet Cell Genet. 1978;22(1-6):498–502. doi: 10.1159/000131007. [DOI] [PubMed] [Google Scholar]
  3. Deisseroth A., Nienhuis A., Turner P., Velez R., Anderson W. F., Ruddle F., Lawrence J., Creagan R., Kucherlapati R. Localization of the human alpha-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay. Cell. 1977 Sep;12(1):205–218. doi: 10.1016/0092-8674(77)90198-2. [DOI] [PubMed] [Google Scholar]
  4. Denhardt D. T. A membrane-filter technique for the detection of complementary DNA. Biochem Biophys Res Commun. 1966 Jun 13;23(5):641–646. doi: 10.1016/0006-291x(66)90447-5. [DOI] [PubMed] [Google Scholar]
  5. Derynck R., Content J., DeClercq E., Volckaert G., Tavernier J., Devos R., Fiers W. Isolation and structure of a human fibroblast interferon gene. Nature. 1980 Jun 19;285(5766):542–547. doi: 10.1038/285542a0. [DOI] [PubMed] [Google Scholar]
  6. Goeddel D. V., Heyneker H. L., Hozumi T., Arentzen R., Itakura K., Yansura D. G., Ross M. J., Miozzari G., Crea R., Seeburg P. H. Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone. Nature. 1979 Oct 18;281(5732):544–548. doi: 10.1038/281544a0. [DOI] [PubMed] [Google Scholar]
  7. Goeddel D. V., Leung D. W., Dull T. J., Gross M., Lawn R. M., McCandliss R., Seeburg P. H., Ullrich A., Yelverton E., Gray P. W. The structure of eight distinct cloned human leukocyte interferon cDNAs. Nature. 1981 Mar 5;290(5801):20–26. doi: 10.1038/290020a0. [DOI] [PubMed] [Google Scholar]
  8. Goeddel D. V., Shepard H. M., Yelverton E., Leung D., Crea R., Sloma A., Pestka S. Synthesis of human fibroblast interferon by E. coli. Nucleic Acids Res. 1980 Sep 25;8(18):4057–4074. doi: 10.1093/nar/8.18.4057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Goeddel D. V., Yelverton E., Ullrich A., Heyneker H. L., Miozzari G., Holmes W., Seeburg P. H., Dull T., May L., Stebbing N. Human leukocyte interferon produced by E. coli is biologically active. Nature. 1980 Oct 2;287(5781):411–416. doi: 10.1038/287411a0. [DOI] [PubMed] [Google Scholar]
  10. Gusella J., Varsanyi-Breiner A., Kao F. T., Jones C., Puck T. T., Keys C., Orkin S., Housman D. Precise localization of human beta-globin gene complex on chromosome 11. Proc Natl Acad Sci U S A. 1979 Oct;76(10):5239–5242. doi: 10.1073/pnas.76.10.5239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Havell E. A., Yip Y. K., Vilcek J. Characteristics of human lymphoblastoid (Namalva) interferon. J Gen Virol. 1978 Jan;38(1):51–59. doi: 10.1099/0022-1317-38-1-51. [DOI] [PubMed] [Google Scholar]
  12. ISAACS A., LINDENMANN J. Virus interference. I. The interferon. Proc R Soc Lond B Biol Sci. 1957 Sep 12;147(927):258–267. doi: 10.1098/rspb.1957.0048. [DOI] [PubMed] [Google Scholar]
  13. Interferon nomenclature. Nature. 1980 Jul 10;286(5769):110–110. doi: 10.1038/286110a0. [DOI] [PubMed] [Google Scholar]
  14. LITTLEFIELD J. W. SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS. Science. 1964 Aug 14;145(3633):709–710. doi: 10.1126/science.145.3633.709. [DOI] [PubMed] [Google Scholar]
  15. Lalley P. A., Brown J. A., Eddy R. L., Haley L. L., Byers M. G., Goggin A. P., Shows T. B. Human beta-glucuronidase: assignment of the structural gene to chromosome 7 using somatic cell hybrids. Biochem Genet. 1977 Apr;15(3-4):367–382. doi: 10.1007/BF00484467. [DOI] [PubMed] [Google Scholar]
  16. Meager A., Graves H. E., Walker J. R., Burke D. C., Swallow D. M., Westerveld A. Somatic cell genetics of human interferon production in human-rodent cell hybrids. J Gen Virol. 1979 Nov;45(2):309–321. doi: 10.1099/0022-1317-45-2-309. [DOI] [PubMed] [Google Scholar]
  17. Meager A., Graves H., Burke D. C., Swallow D. M. Involvement of a gene on chromosome 9 in human fibroblast interferon production. Nature. 1979 Aug 9;280(5722):493–495. doi: 10.1038/280493a0. [DOI] [PubMed] [Google Scholar]
  18. Nagata S., Mantei N., Weissmann C. The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha. Nature. 1980 Oct 2;287(5781):401–408. doi: 10.1038/287401a0. [DOI] [PubMed] [Google Scholar]
  19. Nagata S., Taira H., Hall A., Johnsrud L., Streuli M., Ecsödi J., Boll W., Cantell K., Weissmann C. Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. Nature. 1980 Mar 27;284(5754):316–320. doi: 10.1038/284316a0. [DOI] [PubMed] [Google Scholar]
  20. Naylor S. L., Klebe R. J., Shows T. B. Argininosuccinic aciduria: assignment of the argininosuccinate lyase gene to the pter to q22 region of human chromosome 7 by bioautography. Proc Natl Acad Sci U S A. 1978 Dec;75(12):6159–6162. doi: 10.1073/pnas.75.12.6159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Owerbach D., Bell G. I., Rutter W. J., Brown J. A., Shows T. B. The insulin gene is located on the short arm of chromosome 11 in humans. Diabetes. 1981 Mar;30(3):267–270. doi: 10.2337/diab.30.3.267. [DOI] [PubMed] [Google Scholar]
  22. Owerbach D., Bell G. I., Rutter W. J., Shows T. B. The insulin gene is located on chromosome 11 in humans. Nature. 1980 Jul 3;286(5768):82–84. doi: 10.1038/286082a0. [DOI] [PubMed] [Google Scholar]
  23. Owerbach D., Rutter W. J., Martial J. A., Baxter J. D., Shows T. B. Genes for growth hormone, chorionic somatommammotropin, and growth hormones-like gene on chromosome 17 in humans. Science. 1980 Jul 11;209(4453):289–292. doi: 10.1126/science.7384802. [DOI] [PubMed] [Google Scholar]
  24. Owerbach D., Rutter W. J., Roberts J. L., Whitfeld P., Shine J., Seeburg P. H., Shows T. B. The proopiocortin (adrenocorticotropin/beta-lipoprotein) gene is located on chromosome 2 in humans. Somatic Cell Genet. 1981 May;7(3):359–369. doi: 10.1007/BF01538860. [DOI] [PubMed] [Google Scholar]
  25. Shows T. B., Brown J. A., Eddy R. L., Byers M. G., Haley L. L., Cooper E. S., Goggin A. P. Assignment of peptidase S (PEPS) to chromosome 4 in man using somatic cell hybrids. Hum Genet. 1978 Aug 31;43(2):119–125. doi: 10.1007/BF00293588. [DOI] [PubMed] [Google Scholar]
  26. Shows T. B., Brown J. A., Haley L. L., Byers M. G., Eddy R. L., Cooper E. S., Goggin A. P. Assignment of the beta-glucuronidase structural gene to the pter leads to q22 region of chromosome 7 in man. Cytogenet Cell Genet. 1978;21(1-2):99–104. doi: 10.1159/000130882. [DOI] [PubMed] [Google Scholar]
  27. Shows T. B., Brown J. A. Human X-Linked genes regionally mapped utilizing X-autosome translocations and somatic cell hybrids. Proc Natl Acad Sci U S A. 1975 Jun;72(6):2125–2129. doi: 10.1073/pnas.72.6.2125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Shows T. B., Brown J. A. Mapping AK1, ACONs, and AK3 to chromosome 9 in man employing and X/9 translocation and somatic cell hybrids. Cytogenet Cell Genet. 1977;19(1):26–37. doi: 10.1159/000130791. [DOI] [PubMed] [Google Scholar]
  29. Shows T. B. Genetics of human-mouse somatic cell hybrids: linkage of human genes for lactate dehydrogenase-A and esterase-A 4 . Proc Natl Acad Sci U S A. 1972 Feb;69(2):348–352. doi: 10.1073/pnas.69.2.348. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Shows T. B., McAlpine P. J. The 1979 catalog of human genes and chromosome assignments. Cytogenet Cell Genet. 1979;25(1-4):117–127. doi: 10.1159/000131405. [DOI] [PubMed] [Google Scholar]
  31. Shows T. B., Scrafford-Wolff L. R., Brown J. A., Meisler M. H. GM1-gangliosidosis: chromosome 3 assignment of the beta-galactosidase-A gene (beta GALA). Somatic Cell Genet. 1979 Mar;5(2):147–158. doi: 10.1007/BF01539157. [DOI] [PubMed] [Google Scholar]
  32. Slate D. L., Ruddle F. H. Fibroblast interferon in man is coded by two loci on separate chromosomes. Cell. 1979 Jan;16(1):171–180. doi: 10.1016/0092-8674(79)90198-3. [DOI] [PubMed] [Google Scholar]
  33. Southern E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975 Nov 5;98(3):503–517. doi: 10.1016/s0022-2836(75)80083-0. [DOI] [PubMed] [Google Scholar]
  34. Streuli M., Nagata S., Weissmann C. At least three human type alpha interferons: structure of alpha 2. Science. 1980 Sep 19;209(4463):1343–1347. doi: 10.1126/science.6158094. [DOI] [PubMed] [Google Scholar]
  35. Tan Y. H., Berthold W. A mechanism for the induction and regulation of human fibroblastoid interferon genetic expression. J Gen Virol. 1977 Mar;34(3):401–411. doi: 10.1099/0022-1317-34-3-401. [DOI] [PubMed] [Google Scholar]
  36. Tan Y. H., Creagan R. P., Ruddle F. H. The somatic cell genetics of human interferon: assignment of human interferon loci to chromosomes 2 and 5. Proc Natl Acad Sci U S A. 1974 Jun;71(6):2251–2255. doi: 10.1073/pnas.71.6.2251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Tan Y. H., Schneider E. L., Tischfield J., Epstein C. J., Ruddle F. H. Human chromosome 21 dosage: effect on the expression of the interferon induced antiviral state. Science. 1974 Oct 4;186(4158):61–63. doi: 10.1126/science.186.4158.61. [DOI] [PubMed] [Google Scholar]
  38. Taylor J. M., Illmensee R., Summers J. Efficeint transcription of RNA into DNA by avian sarcoma virus polymerase. Biochim Biophys Acta. 1976 Sep 6;442(3):324–330. doi: 10.1016/0005-2787(76)90307-5. [DOI] [PubMed] [Google Scholar]
  39. Wahl G. M., Stern M., Stark G. R. Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proc Natl Acad Sci U S A. 1979 Aug;76(8):3683–3687. doi: 10.1073/pnas.76.8.3683. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Wheelock E. F. Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin. Science. 1965 Jul 16;149(3681):310–311. [PubMed] [Google Scholar]

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