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. 1986 Jul;83(14):5219–5222. doi: 10.1073/pnas.83.14.5219

Human chromosome 7 carries the beta 2 interferon gene.

P B Sehgal, A Zilberstein, R M Ruggieri, L T May, A Ferguson-Smith, D L Slate, M Revel, F H Ruddle
PMCID: PMC323922  PMID: 3014537

Abstract

A cDNA clone (pAE20-4) corresponding to the 1.3-kilobase human beta 2 interferon mRNA was used as a probe in blot-hybridization experiments of DNA from a panel of human-rodent somatic cell hybrids containing overlapping subsets of human chromosomes. The DNA hybridization experiments showed that the human beta 2 interferon gene is located on human chromosome 7. This assignment is consistent with previous experimental data in which the expression of the translationally active 1.3-kilobase beta 2 interferon mRNA was assayed in various somatic cell hybrids. Blot-hybridization experiments using DNA from different human cell strains and cell lines reveal distinct EcoRI restriction fragment length polymorphisms of the human beta 2 interferon gene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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