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. 1984 Mar;81(6):1774–1778. doi: 10.1073/pnas.81.6.1774

Class II HLA-DC beta-chain DNA restriction fragments differentiate among HLA-DR2 individuals in insulin-dependent diabetes and multiple sclerosis.

D Cohen, O Cohen, A Marcadet, C Massart, M Lathrop, I Deschamps, J Hors, E Schuller, J Dausset
PMCID: PMC345003  PMID: 6324215

Abstract

HLA-DR2 allele is negatively associated with insulin-dependent diabetes and positively associated with multiple sclerosis (MS). A 2.2-kilobase-pair EcoRI DNA restriction fragment detected with a beta-chain HLA-DC cDNA probe was found to be strongly correlated with HLA-DR2 in the normal population, but was absent in HLA-DR2 insulin-dependent diabetic patients. This fragment was found in HLA-DR2 multiple sclerosis patients with the same frequency as in controls. A beta-chain HLA-DC 12-kilobase-pair BamHI fragment might differentiate multiple sclerosis patients from healthy individuals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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