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. 1989 Nov;9(11):5219–5222. doi: 10.1128/mcb.9.11.5219

Evidence for multiple major histocompatibility class II X-box binding proteins.

A Celada 1, R Maki 1
PMCID: PMC363675  PMID: 2513482

Abstract

The X box is a loosely conserved DNA sequence that is located upstream of all major histocompatibility class II genes and is one of the cis-acting regulatory elements. Despite the similarity between all X-box sequences, each promoter-proximal X box in the mouse appears to bind a separate nuclear factor.

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Selected References

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  1. Basta P. V., Sherman P. A., Ting J. P. Detailed delineation of an interferon-gamma-responsive element important in human HLA-DRA gene expression in a glioblastoma multiform line. Proc Natl Acad Sci U S A. 1988 Nov;85(22):8618–8622. doi: 10.1073/pnas.85.22.8618. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Blanar M. A., Burkly L. C., Flavell R. A. NF-kappa B binds within a region required for B-cell-specific expression of major histocompatibility complex class II gene E alpha d. Mol Cell Biol. 1989 Feb;9(2):844–846. doi: 10.1128/mcb.9.2.844. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Boothby M., Liou H. C., Glimcher L. H. Differences in DNA sequence specificity among MHC class II X box binding proteins. J Immunol. 1989 Feb 1;142(3):1005–1014. [PubMed] [Google Scholar]
  4. Boss J. M., Strominger J. L. Regulation of a transfected human class II major histocompatibility complex gene in human fibroblasts. Proc Natl Acad Sci U S A. 1986 Dec;83(23):9139–9143. doi: 10.1073/pnas.83.23.9139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Celada A., Maki R. A. DNA binding of the mouse class II major histocompatibility CCAAT factor depends on two components. Mol Cell Biol. 1989 Jul;9(7):3097–3100. doi: 10.1128/mcb.9.7.3097. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Celada A., Shiga M., Imagawa M., Kop J., Maki R. A. Identification of a nuclear factor that binds to a conserved sequence of the I-A beta gene. J Immunol. 1988 Jun 1;140(11):3995–4002. [PubMed] [Google Scholar]
  7. Dorn A., Benoist C., Mathis D. New B-lymphocyte-specific enhancer-binding protein. Mol Cell Biol. 1989 Jan;9(1):312–320. doi: 10.1128/mcb.9.1.312. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Dorn A., Durand B., Marfing C., Le Meur M., Benoist C., Mathis D. Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins. Proc Natl Acad Sci U S A. 1987 Sep;84(17):6249–6253. doi: 10.1073/pnas.84.17.6249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Flavell R. A., Allen H., Burkly L. C., Sherman D. H., Waneck G. L., Widera G. Molecular biology of the H-2 histocompatibility complex. Science. 1986 Jul 25;233(4762):437–443. doi: 10.1126/science.3726537. [DOI] [PubMed] [Google Scholar]
  10. Hatamochi A., Golumbek P. T., Van Schaftingen E., de Crombrugghe B. A CCAAT DNA binding factor consisting of two different components that are both required for DNA binding. J Biol Chem. 1988 Apr 25;263(12):5940–5947. [PubMed] [Google Scholar]
  11. King D. P., Jones P. P. Induction of Ia and H-2 antigens on a macrophage cell line by immune interferon. J Immunol. 1983 Jul;131(1):315–318. [PubMed] [Google Scholar]
  12. Koch W., Benoist C., Mathis D. Anatomy of a new B-cell-specific enhancer. Mol Cell Biol. 1989 Jan;9(1):303–311. doi: 10.1128/mcb.9.1.303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Koch W., Candeias S., Guardiola J., Accolla R., Benoist C., Mathis D. An enhancer factor defect in a mutant Burkitt lymphoma cell line. J Exp Med. 1988 Jun 1;167(6):1781–1790. doi: 10.1084/jem.167.6.1781. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Liou H. C., Boothby M. R., Glimcher L. H. Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element. Science. 1988 Oct 7;242(4875):69–71. doi: 10.1126/science.3140376. [DOI] [PubMed] [Google Scholar]
  15. Mathis D. J., Benoist C. O., Williams V. E., 2nd, Kanter M. R., McDevitt H. O. The murine E alpha immune response gene. Cell. 1983 Mar;32(3):745–754. doi: 10.1016/0092-8674(83)90060-0. [DOI] [PubMed] [Google Scholar]
  16. Miwa K., Doyle C., Strominger J. L. Sequence-specific interactions of nuclear factors with conserved sequences of human class II major histocompatibility complex genes. Proc Natl Acad Sci U S A. 1987 Jul;84(14):4939–4943. doi: 10.1073/pnas.84.14.4939. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Noelle R. J., Kuziel W. A., Maliszewski C. R., McAdams E., Vitetta E. S., Tucker P. W. Regulation of the expression of multiple class II genes in murine B cells by B cell stimulatory factor-1 (BSF-1). J Immunol. 1986 Sep 1;137(5):1718–1723. [PubMed] [Google Scholar]
  18. Polla B. S., Poljak A., Geier S. G., Nathenson S. G., Ohara J., Paul W. E., Glimcher L. H. Three distinct signals can induce class II gene expression in a murine pre-B-cell line. Proc Natl Acad Sci U S A. 1986 Jul;83(13):4878–4882. doi: 10.1073/pnas.83.13.4878. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Reith W., Barras E., Satola S., Kobr M., Reinhart D., Sanchez C. H., Mach B. Cloning of the major histocompatibility complex class II promoter binding protein affected in a hereditary defect in class II gene regulation. Proc Natl Acad Sci U S A. 1989 Jun;86(11):4200–4204. doi: 10.1073/pnas.86.11.4200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Reith W., Satola S., Sanchez C. H., Amaldi I., Lisowska-Grospierre B., Griscelli C., Hadam M. R., Mach B. Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X. Cell. 1988 Jun 17;53(6):897–906. doi: 10.1016/s0092-8674(88)90389-3. [DOI] [PubMed] [Google Scholar]
  21. Saito H., Maki R. A., Clayton L. K., Tonegawa S. Complete primary structures of the E beta chain and gene of the mouse major histocompatibility complex. Proc Natl Acad Sci U S A. 1983 Sep;80(18):5520–5524. doi: 10.1073/pnas.80.18.5520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Sherman P. A., Basta P. V., Ting J. P. Upstream DNA sequences required for tissue-specific expression of the HLA-DR alpha gene. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4254–4258. doi: 10.1073/pnas.84.12.4254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Sittisombut N. Two distinct nuclear factors bind the conserved regulatory sequences of a rabbit major histocompatibility complex class II gene. Mol Cell Biol. 1988 May;8(5):2034–2041. doi: 10.1128/mcb.8.5.2034. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Sullivan K. E., Peterlin B. M. Transcriptional enhancers in the HLA-DQ subregion. Mol Cell Biol. 1987 Sep;7(9):3315–3319. doi: 10.1128/mcb.7.9.3315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Tsang S. Y., Nakanishi M., Peterlin B. M. B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene. Proc Natl Acad Sci U S A. 1988 Nov;85(22):8598–8602. doi: 10.1073/pnas.85.22.8598. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Wong G. H., Clark-Lewis I., McKimm-Breschkin L., Harris A. W., Schrader J. W. Interferon-gamma induces enhanced expression of Ia and H-2 antigens on B lymphoid, macrophage, and myeloid cell lines. J Immunol. 1983 Aug;131(2):788–793. [PubMed] [Google Scholar]

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