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. 1983 Apr;80(8):2127–2131. doi: 10.1073/pnas.80.8.2127

Nucleotide sequence of the human parathyroid hormone gene.

T J Vasicek, B E McDevitt, M W Freeman, B J Fennick, G N Hendy, J T Potts Jr, A Rich, H M Kronenberg
PMCID: PMC393770  PMID: 6220408

Abstract

From a lambda phage gene library we have isolated phage containing the gene encoding human preproparathyroid hormone. The phage were isolated by using both the plaque-hybridization technique and the in vivo recombination-selection technique. The human preproparathyroid hormone gene contains two intervening sequences that separate the gene into a 5' noncoding domain, a "prepro" sequence domain, and a domain containing the parathyroid hormone sequence and the 3' noncoding region. The gene is approximately 4,200 base pairs long. Restriction endonuclease analysis of human leukocyte DNA shows that the haploid human genome contains one copy of the preproparathyroid hormone gene. A 14-base-pair sequence of alternating purines and pyrimidines that has the potential of adopting the Z-DNA conformation lies 134 base pairs upstream from the presumed site of initiation of transcription.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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