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. 1972 Mar;69(3):721–725. doi: 10.1073/pnas.69.3.721

Enhancement by Interferon of the Specific Cytotoxicity of Sensitized Lymphocytes

Pernilla Lindahl 1, Patricia Leary 1, Ion Gresser 1
PMCID: PMC426543  PMID: 4501586

Abstract

Mouse interferon preparations enhanced the specific cytotoxicity of sensitized lymphocytes for allogeneic target tumor cells. The factor responsible for the enhancement of cytotoxicity could not be dissociated from the antiviral activity of interferon by standard physicochemical means. Thus, in addition to its well-known antiviral activity, and its effect on cell division, interferon also appears to enhance a specialized cellular function. It is suggested that a common mechanism of action underlies these seemingly different biologic phenomena, and that interferon may play a role in the regulation of fundamental cellular processes.

Keywords: target tumor cells, mouse spleen, lymphoid leukemia, 51Cr release

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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