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. 1974 Sep;71(9):3659–3663. doi: 10.1073/pnas.71.9.3659

Organization of Immunoglobulin Genes: Reiteration Frequency of the Mouse κ Chain Constant Region Gene

T Honjo 1, S Packman 1, D Swan 1, M Nau 1, P Leder 1
PMCID: PMC433835  PMID: 4215083

Abstract

Hybridization kinetic analyses with synthetic DNA indicate that there are only two to three copies of the κ constant region gene per haploid genome. This result lends weight to the argument that the immunoglobulin light chain is encoded by more than one continuous gene sequence.

Keywords: gene reiteration, hybridization, synthetic DNA, mRNA

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Selected References

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